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Stop Animal
Exploitation NOW!
S. A. E. N.
"Exposing the truth to wipe
out animal experimentation"
Government Grants Promoting Cruelty to Animals
University of Washington, Seattle, WA
CHRIS R. S. KANEKO - Primate Testing - 2006
Grant Number: 5R01EY006558-19
Project Title: Saccadic Eye Movement Studies
PI Information: RESEARCH SCIENTIST, IV CHRIS R S. KANEKO,
[email protected]
Abstract: DESCRIPTION (provided by applicant): The long-term objective of this research is to understand how the brain
translates sensory information into the commands for movements. The
oculomotor system is an excellent model for study because of its simple
peripheral mechanics and musculature and the ease with which eye
movements can be accurately measured. Because of these advantages, the
component neuron types, their discharge patterns, and many of the
connections of various oculomotor subsystems are comparatively well
understood. Perhaps the most-studied type of eye movements is the quick,
scanning movements called saccades. The specific goal of our research is
to continue this detailed description in order to provide a basis for
determining how the neural components actually produce saccades and to
serve as a foundation for the study of higher-order neural processes.
Recent studies have implicated the midline cerebellum in the direct
control of saccades. Our specific aims are to begin to investigate its
contribution. The major brainstem input to the cerebellum is from the
nucleus reticularis tegmenti pontis (nrtp) so we will assess the
function of the nrtp using recording, electrical stimulation and
reversible (in) activation with neuroactive agents. We will study nrtp
neurons during normal saccades and in paradigms in which the animal is
required to adapt the amplitude of the saccade. We suggest that the nrtp
pathway mediates feed forward and feedback control of saccades and hope
to quantify this hypothesis based on the information we will provide in
these studies. Because accurate eye movements are essential for clear
vision, these studies contribute to our understanding of normal visual
mechanisms. They also provide an example of how the nervous system
processes (visual) sensory information into (saccadic) motor responses
and may help to interpret studies of the intervening processes like
(visual) target selection. Finally, the diagnosis and localization of
nervous system dysfunction resulting from a wide variety of causes has
been significantly advanced by the characterization of oculomotor
functions (i.e., eye signs).
Thesaurus Terms: eye movement, neural information processing, neuron, saccade,
sensorimotor system, superior colliculus, visual feedback central neural
pathway /tract, neurophysiology, pons, visual stimulus Macaca mulatta,
electrophysiology, electrostimulus
Institution: UNIVERSITY OF WASHINGTON Office of Sponsored Programs, SEATTLE, WA 98105
Fiscal Year: 2006 Department: PHYSIOLOGY AND BIOPHYSICS
Project Start: 01-SEP-1986 Project End: 31-MAR-2009
ICD: NATIONAL EYE INSTITUTE IRG: ZRG1
Neurophysiol 95: 979-994, 2006. First published
October 19, 2005
Saccade-Related, Long-Lead Burst Neurons in the Monkey
Rostral Pons
Chris R. S. Kaneko
Department of Physiology and Biophysics and Washington National Primate
Research Center, University of Washington, Seattle, Washington
Submitted 19 July 2005; accepted in final form 17 October 2005
In brief, four juvenile (3�5 kg), male rhesus macaques (Macaca
mulatta; monkeys O, M, H, and B) were anesthetized and implanted with a
scleral search coil (Fuchs and Robinson 1966 ), a recording chamber, and
head-stabilization lugs in aseptic surgery. The technique was that
described by Judge et al. (1980 ), modified so that the lead wire exits
though a hole drilled in the back orbit (cf. Kaneko et al. 1981 ). After
they recovered, the monkeys were trained to track a moveable,
back-projected laser spot for food reward. |
Please email: CHRIS R. S. KANEKO,
[email protected] to protest the inhumane use of animals in this
experiment. We would also love to know about your efforts with this
cause:
[email protected]
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Rats, mice, birds, amphibians and other animals have
been excluded from coverage by the Animal Welfare Act. Therefore research
facility reports do not include these animals. As a result of this
situation, a blank report, or one with few animals listed, does not mean
that a facility has not performed experiments on non-reportable animals. A
blank form does mean that the facility in question has not used covered
animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs,
sheep, goats, etc.). Rats and mice alone are believed to comprise over 90%
of the animals used in experimentation. Therefore the majority of animals
used at research facilities are not even counted.
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