Brooks Air Force Base

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Facility Reports and Information

Brooks Air Force Base, TX

Protocol - 2003-20 - Effects of Microwave Radiation on Nigrostriatal Neurodegeneration in the Rat

 

Title:

Effects of Microwave Radiation on Nigrostriatal Neurodegeneration in the Rat

 

Research Category:

M8: Neurotoxin Research

 

FY: 2003 Funding (in dollars):

208,000

 

Responsible Organization:

AIR FORCE RESEARCH LAB/BROOKS

Primary Contact:

Public Affairs Office

City:

Brooks City-Base

State:

TX

Zip:

78235-5116

 

Performing Organization:

See Responsible Organization Information

City:

 

State:

 

Zip:

 

 

Keywords:

LABORATORY ANIMALS NEURODEGENERATION PULSED MICROWAVES NEUROTOXIN AKINESIA IMMUNOHISTOCHEMISTRY TYROSINE HYDROXYLASE DNA DAMAGE PARKINSON'S DISEASE

 

Objective:

The goal of this study is to use an animal model to determine whether exposure to microwave radiation similar to that used in military environments affects the nigrostriatal dopaminergic pathway and whether the exposure increases the risk of Parkinson's disease.

 

Approach:

The study investigates effects of microwave exposure on the nigrostriatal system using rotenone in Lewis rats as a model. Animals were implanted with osmotic pumps to provide chronic infusion of rotenone at different doses and durations to identify appropriate dosing parameters for use with later exposures to pulsed L band microwaves at whole-body specific absorption rate of 0, 0.4, or 4 W/kg in daily 6 min exposures. Forelimb use and locomotor activity were tested weekly to assess nigrostriatal function over 3 weeks. Changes in brain neurochemistry were assessed at 3 weeks through measurement of tyrosine hydroxylase and OX-42 by immunohistochemistry. This work supports the USAMRMC Neurotoxin Exposure Treatment Research Program (NETRP), which recognizes that military occupational exposures have the potential to increase the risk of neuronal injury. This work assists in establishing the biomedical and physiological database required to assess US Army hazards as required by Army Regulation 40-10.

 

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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